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KMID : 0923620130130060240
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Immune Network
2013 Volume.13 No. 6 p.240 ~ p.248
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Increased Lymphocyte Infiltration in Rheumatoid Arthritis Is Correlated with an Increase in LTi-like Cells in Synovial Fluid
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Koo Ji-Hye
Kim Soo-Chan
Jung Woong-Jae
Lee Ye-Eun
Song Gwan-Gyu
Kim Kyung-Su
Kim Mi-Yeon
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Abstract
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In this study, we compared the immune cell populations in rheumatoid arthritis (RA) synovial fluid, which shows lym-phoid tissue-like structure, with those in tonsils, which are normal secondary lymphoid tissues. Firstly, we found that CD4?CD11b＋ macrophages were the major population in RA synovial fluid and that B cells were the major population in tonsils. In addition, synovial fluid from patients with osteo-arthritis, which is a degenerative joint disease, contained CD4＋CD11b＋ monocytes as the major immune cell pop-ulation. Secondly, we categorized three groups based on the proportion of macrophages found in RA synovial fluid: (1) the macrophage-high group, which contained more than 80% macrophages; (2) the macrophage-intermediate group, which contained between 40% and 80% macrophages; and (3) the macrophage-low group, which contained less than 40% macrophages. In the macrophage-low group, more lym-phoid tissue inducer (LTi)-like cells were detected, and the expression of OX40L and TRANCE in these cells was higher than that in the other groups. In addition, in this group, the suppressive function of regulatory T cells was downregulat-ed. Finally, CXCL13 expression was higher in RA synovial flu-id than in tonsils, but CCL21 expression was comparable in synovial fluid from all groups and in tonsils. These data dem-onstrate that increased lymphocyte infiltration in RA synovial fluid is correlated with an increase in LTi-like cells and the el-evation of the chemokine expression.
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KEYWORD
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Lymphoid tissue inducer, Rheumatoid arthritis, Tonsil
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